Heart of the Matter · 2025-10-21 · 39 min
Key moments - from our scoring
Substance score
44 / 100
Five dimensions, 20 points each
Dr. Kristen Gilliland brings both personal tragedy and scientific expertise to a discussion about the neurobiology of high-potency cannabis and its effects on adolescent brain development. Her son Anders began smoking marijuana in middle school around age 13-14, developed psychotic symptoms by 17, was diagnosed with schizophrenia, and died from an accidental overdose on March 4, 2019, after spiraling into cocaine and heroin addiction. What makes her message urgent is the dramatic shift in cannabis potency: products from the 1970s-90s contained 1-5% THC, while today's cannabis flowers range from 20-30% THC and concentrates can reach 90%. Gilliland explains how the endocannabinoid system - which acts as the brain's thermostat for neural communication during adolescence - becomes hijacked by THC, disrupting the critical pruning and development of the prefrontal cortex (which doesn't fully mature until age 24-25). Her identical twin sons both developed schizophrenia, suggesting genetic vulnerability may interact with THC exposure. Recent data from a May 2025 American Journal of Addiction study shows states that legalized marijuana recreationally and medically saw increased overdose deaths in adolescents aged 14-18. She emphasizes that while overall US overdose rates have declined, cannabis legalization has created a gateway effect where adolescents move from cannabis to opioids and stimulants.
Cannabis from the 1970s-90s contained 1-5% THC, while today's cannabis flowers contain 20-30% THC and some concentrates reach 90% THC, representing a dramatic increase in the psychoactive substance.
The prefrontal cortex, which governs decision-making and understanding consequences, does not fully develop until around age 24-25, making adolescents particularly vulnerable to THC's effects on brain development.
THC hijacks the endocannabinoid system by binding to cannabinoid receptors and prematurely stopping neural communication even when development still requires that communication, disrupting the brain's natural pruning process and prefrontal cortex maturation.
While not all cannabis use causes schizophrenia, there is a documented association between cannabis use - particularly high-potency products - and increased risk of developing psychosis and schizophrenia, especially in adolescents with genetic predisposition and those using cannabis before age 19.
Yes, according to a May 2025 study in the American Journal of Addiction, states that legalized marijuana recreationally and medically saw increases in overdose deaths among adolescents aged 14-18 from all types of drugs, suggesting cannabis acts as a gateway drug.
Our reviewer’s read on each dimension, with quotes from the episode.
The episode contains legitimate scientific explanations of how THC affects adolescent brain development, particularly regarding the endocannabinoid system and prefrontal cortex development. However, much of the content is anecdotal narrative about Anders' decline rather than novel insights - the core claims (high THC potency, earlier brain development vulnerability, psychosis risk) are well-established public health messaging. The deep dive into endocannabinoid system mechanics is substantive but takes up limited time relative to personal story retelling.
weed, if I can call it weed or marijuana from the in, you know, 70s, even the 90s was 1 to 5% THC, the psychoactive substance that gives the high feeling. Mhm. Where now it's anywhere between 20 to 30% in the cannabis flower. What, you know, people are smoking and some of these concentrates that these kids are using can be as high as 90% THC.
the endocannabinoid system, it actually serves as regulating all the communication in the brain. And so where the gas is needed and where brakes are needed, you know, in development, making sure that everything is communicating beautifully.
The core argument - that high-potency marijuana poses risks to adolescent brain development and can trigger psychosis - is well-established in public health discourse and peer-reviewed literature cited by the guest. The conversation relies heavily on conventional wisdom about prefrontal cortex development, gateway drugs, and addiction pathways. While the epigenetics angle and endocannabinoid system mechanics add some depth, they are not presented as novel findings but as established neuroscience. The framing is advocacy-oriented rather than contrarian or first-principles.
there is an association between cannabis use or marijuana use and psychosis. Definitely an association.
25 is when your prefrontal cortex develops. Well, using marijuana, it actually delays that development.
Dr. Gilliland holds legitimate neuroscience credentials and has done real research on the endocannabinoid system. However, she is primarily positioned as a grief-driven advocate leveraging her personal tragedy rather than as an active researcher or operator with ongoing scientific practice. She teaches a curriculum and runs a nonprofit, but the transcript provides no evidence of current peer-reviewed research output, lab leadership, or ongoing scientific contributions. Her credibility rests substantially on her personal experience rather than demonstrated scientific standing.
I was actually teaching a course in neurochemistry at that time period.
I went deep into really understanding the, what's called the endocannabinoid system where THC interacts, um, within your, you know, your brain and body to learn its function in the adolescent brain.
The episode provides some concrete data points: THC potency ranges (1-5% historically, 20-30% now, up to 90% in concentrates), age-based risk windows (before age 19 critical, fully developed by 25), specific medications (Anders on antipsychotics), a May 2025 study on overdose increases in states with legal cannabis. However, many claims lack specificity: no named researchers or institutions, no actual statistics on psychosis incidence, vague references to 'studies' without citations, and the critical causal claim about Anders relies on inference rather than diagnostic evidence. Personal narrative dominates over hard numbers.
an article that just came out in May of 20, uh, 25, and it's in the American Journal of Addiction. And the study focused on looking at all the states, looking at which states had legalized marijuana and then looking at overdose, the amounts of overdoses between adolescents who are 14 to 18 years old.
the latest CDC numbers showed 40% of high school students feel a sense of hopelessness and a sense of persistent sadness. 20% have seriously considered suicide, and 10% tried.
The host asks clarifying follow-ups and allows the guest space to explain complex concepts, demonstrating basic interview competence. However, the conversation rarely pushes back or challenges claims. When the guest herself backtracks on causation language ('I shouldn't say cause because I think that's a strong word'), the host accepts this softening without pressing. The host does not probe potential counterarguments, alternative explanations, or limitations of the evidence. Questions are mostly open and exploratory rather than forensic, and the tone is sympathetic rather than skeptical, which suits the personal narrative but reduces intellectual rigor.
Do we know how big that risk is? I mean, is it a small risk? Is it a medium high risk?
And why do you think or why did the psychiatrist think that the psychotic episodes were linked to the marijuana use and not to the other drugs?
Computed from the transcript - who did the talking, and the words that came up most.
After losing one son to overdose and watching another struggle with lifelong schizophrenia, neuroscientist Dr. Kristen Gilliland reveals what she wishes she'd known about today's ultra-potent marijuana and the developing brain. She breaks down the science of how THC hijacks the adolescent brain's critical development period and why the push for marijuana legalization may be putting more teens at risk. Content warning: This episode contains mentions of death, as well as in-depth discussions of substance use. If you or someone you know is struggling with a mental health or substance use disorder, please contact SAMHSA’s National Helpline at (800) 662-4357. These programs provide free, confidential support 24/7. You are not alone. Explore more on topics and themes discussed in this episode : Marijuana Resource Center Co-Occurring Disorders Resource Center Having Tough Conversations Editor’s Note : The views and opinions expressed on “Heart of the Matter” are those of the podcast participants and do not necessarily reflect the official policy or position of Partnership to End Addiction.
Transcribed and scored by The B2B Podcast Index.
Speaker A: Hello everyone, and welcome to Heart of the Matter. I'm, um, your host, Elizabeth Vargas, and we have a guest. I am so excited for you to hear from her. I've had her on my show at News Nation. We've obviously recorded this podcast here on Heart of the Matter. Her name is Dr. Kristen Gilliland and she's a neuroscientist. She studies the brain. She's also a mom of two twin sons, both of whom she says developed perhaps schizophrenia from using marijuana. Uh, there's an increasing incidence in this country of marijuana induced psychosis. We're seeing this in emergency rooms, doctors are seeing this. And she is studying this. The pot out there on the streets today that everybody seems to be smoking that you smell in so many major cities in this country. It is very, very, very different from the pot that people were smoking way back when I was growing up. At least it is. Its potency has increased dramatically, dramatically. And it is causing, according to Dr. Gilliland, a lot of issues. She lost one of her sons, Anders, at the age of 22 after he accidentally overdosed. He'd been struggling with anxiety as a teenager, began using pot to self medicate to help calm himself, and that led to an addiction of opioids and stimulants. Dr. Gilliland is now studying this. She's got a lot of obviously tragic personal experience with this, but it's an important message to hear. She's done a TED Talk, she's done a documentary called Speaking Through Me. That's incredible. I encourage everybody to watch it. But without further ado, here's my conversation with Dr. Kristen Gilliland. Doctor Kristen Gilliland, thank you so much. Welcome to Heart of the Matter. It's great to have you on the show today. I am so fascinated by your work in this area. Your documentary is incredible and a real warning, important warning for parents everywhere because so many kids these days are smoking pot. It feels like everywhere I go, I smell it. And this whole societal attitude we have now toward marijuana, which is, ah, uh, it's nothing. It's like, you know, a beer, right? And you're really sounding the warning on it.
Speaker B: You know, I'm, I'm doing what I can and it comes from personal experience of having my son. At that time, I didn't know that there was such a difference in potency. And I believe that's what most people understand, right is there is a huge difference in potency where, you know, weed, if I can call it weed or marijuana from the in, you know, 70s, even the 90s was 1 to 5% THC, the psychoactive substance that gives the high feeling. Mhm. Where now it's anywhere between 20 to 30% in the cannabis flower. What, you know, people are smoking and some of these concentrates that these kids are using can be as high as 90% THC.
Speaker A: Oh my gosh.
Speaker B: Yes. And a lot of people don't understand this. And I, you know, if I could go back in my time machine, I, I didn't know at that time period, uh, I was in California where it was legalized and they're pot farms.
Speaker A: There are businesses that just grow pot and they're making good money doing it.
Speaker B: Exactly. And, and because it's legal, everybody just has this perception that it's safe. I mean, how would they legalize it if it was dangerous? Well, I mean, we can look at other things. Alcohol, Nic, you know, in that, in that sense too. But when my son started using it, I never imagined that it could cause psychosis and then eventually turn into schizophrenia. And I'm not going to say I shouldn't say cause because I think that's a strong word. But there is an association between cannabis use or marijuana use and psychosis. Definitely an association. And I think it's a number of factors that increase the risk of developing psychosis, which, you know, I can go into later if you want me to.
Speaker A: Sure. Well, let's talk about Anders. Very quickly. How old was he when he started smoking pot?
Speaker B: Uh, he was, you know, high school, kind of around. And as a, uh, parent, definitely, you know, you could smell it. Right. And walk in and say, okay, you've been doing this. No, I haven't. Uh, yeah, you have. And so started in middle school and just trying to have those talks. No, you know, you don't want to do this. Um, but kids are kids, you know. And also, I will say, uh, it was very accessible at that time because it was legal for medical purposes and so people could get their, you know, their medical card. But, you know, I just didn't have that, that sense of urgency to say, don't do this, because I just didn't know the difference again, in potency and uh, what that can do to the developing brain.
Speaker A: And let's just remind our audience you're a neuroscientist. I mean, this is your expertise. And even you didn't know at that time.
Speaker B: Well, I was, yeah, so I, you know, I was actually teaching a course in neurochemistry at that time period. And yeah, I didn't understand the potency difference. And you know, what I will say is I learned a lot about, I, uh, taught a lot about the adult brain and was not focused as much on the adolescent brain. And so then when all of this started to happen to my son, that's when I did a lot of research. I went deep into really understanding the, what's called the endocannabinoid system where THC interacts, um, within your, you know, your brain and body to learn its function in the adolescent brain. And that's when it was a, oh my gosh. Moment, you know, like, oh, this is, this is really bad. And I think if every parent understood the purpose of that system, they would look at marijuana, weed, cannabis in a whole different light.
Speaker A: Uh, when did you begin to notice things that weren't right? You knew he was smoking pot. Most a lot of kids are smoking pot. You didn't know about the difference in the levels of THC in today's pot versus the pot. That was around when you and I were growing up. What did you first start to notice that started ringing alarm bells for you?
Speaker B: When he was 17, he started showing symptoms of psychosis. He began to see things, hear voices, see things that weren't there. And his father and I at the time brought him to, uh, a psychiatrist. And that's when he, the psychiatrist actually asked, all right, have you been using marijuana? And yeah, and that's when he said yes. And later we were informed that yes, this can actually cause we're. And it was, you know, pretty new. It uh, was like 2000, I guess it would have been about 2013 when, you know, the psychiatrist said, we're just starting to see studies showing that using marijuana is related to an increased risk of developing psychosis.
Speaker A: Do we know how big that risk is? I mean, is it a small risk? Is it a medium high risk?
Speaker B: So it's, it's, it's actually. So it is very low. I do want to say that it is very low, but there is an increased risk with using cannabis. But when we look at psychosis, we do know that there are risk factors that increase this. And we have seen an increase in psychosis coming into hospital settings, into emergency department settings of, um, people developing psychosis, but it might be short term psychosis that once they stop using the cannabis product that it goes away. But the big warning is, is that a lot of people don't realize that and they continue to use. And I believe that's what happened with my son, is that he had that warning where he had those psychos, psychotic episodes.
Speaker A: Mhm.
Speaker B: But he continued to use and then it developed into schizophrenia.
Speaker A: Did you try to get him to stop, given what the psychiatrist told you? Well, yeah, that there might be a link.
Speaker B: Well, he, at that time, um, he had also started to use some other drugs and so he had fallen into other addiction as well. So he had actually, after just cannabis, started using, um, opioids and, and stimulants. So, so it was very hard to, to even have to, you know, of course, tell him just to stop cannabis. But also when you. He had started to, to do. He wasn't. I wouldn't say that he was completely in full blown addiction then or, you know, it was later on during, like in his 20s or so, where he really developed an addiction to cocaine and, and heroin.
Speaker A: And why do you think or why did the psychiatrist think that the psychotic episodes were linked to the marijuana use and not to the other drugs?
Speaker B: Well, and this is, this is an important point and that there definitely are other drugs like cocaine and that kit that can lead to that. Um, so there is that potential for sure. The one point that I, I will make is that he has a twin brother and his twin brother, who was primarily a cannabis user, also has schizophrenia. So, uh. Yeah, I know.
Speaker A: Wow.
Speaker B: Yeah. So it's been a, uh, it's been quite a journey. And I think the developing brain, the studies that have come out between the ages of three, you know, I should say before 19 years old, the risk of developing psychosis from using marijuana is much higher than after 19 because the brain is more developed after 19. So when you understand that there are multiple factors that can lead to psychosis, and when you understand about the endocannabinoid system and how it plays a role in the development of the prefrontal cortex. Um, you know, most kids hear it. So 25 is when your prefrontal cortex develops. Well, using marijuana, it actually delays that development. And, and so these are, these are, um, points that need to be brought up. They need, it needs to be out and just understanding that. But people who have someone in their family, particularly a first relative that has schizophrenia or bipolar disorder, m the use of high potency marijuana, which is any cannabis product that has a level of THC greater than 10% by weight.
Speaker A: I was going to say, how does anybody even know when these kids are going into these, you know, uh, stores? They're everywhere in New York City and I've seen them all over California and other states are now legalizing marijuana for various uses. There are all sorts of businesses popping up. Do they list the thc levels.
Speaker B: They have to. I think that's one of the. The requirements. But whether or not how true it is on, um, you know, what. What it is, they have to say the ingredients of what. What is in there. But there's not much. There's not a regulatory process. And that's. That's one thing too, is that everybody believes it's safe, but the FDA doesn't regulate. They don't go in and regulate these
Speaker A: products to make sure what they're saying is true.
Speaker B: Exactly. And every state has their own regulatory, you know, um, like the guide that every dispensary has to go through. But it's. It. It differs by state.
Speaker A: So by the time that Anders was diagnosed and he was really suffering from addiction, and you believe, and there's science to back this up, that starting one drug opens the door to the next drug, to the next drug, to the next drug. I mean, there has long been debate about marijuana for precisely this reason, that it's a, quote, gateway drug.
Speaker B: Right.
Speaker A: That will lead to the abuse of other drugs eventually. Is that right? And that's what happened with Anders.
Speaker B: Yes. And, you know, he was hanging out with. With friends who all were. Experience, you know, experimenting at that time period. And I do believe that the one thing that I do want to mention, and there was an article that just came out in May of 20, uh, 25, and it's in the American Journal of Addiction. And the study focused on looking at all the states, looking at which states had legalized marijuana and then looking at overdose, the amounts of overdoses between adolescents who are 14 to 18 years old. Even though as our national levels of overdose have decreased. Which is awesome. It's great. Um, all the states that had legalized marijuana recreationally and medically, they saw an increase in overdose Deaths for kids 14 to 18 from all different kinds of drugs. Um, yes, yes. And that just came out this year. And so this is another study that needs to be out there. And I'm sure you're probably aware about right now, there's a push to reschedule
Speaker A: marijuana, and the federal government wants to reschedule marijuana to a less dangerous classification, which would make it easier to get and less regulated.
Speaker B: Right. And so. But also they say it will be for, um. So there can be more medical studies done on it and looking at its benefits. And, you know, I'm all for. Because there are so many chemicals in the plant, particularly called cannabinoids, that and other chemicals that can probably have some great benefits, you know, but we'd have to Tease them out. There are hundreds of them. And so you'd have to tease out all of them. So I do think that that's good. However, uh, one of the big red flags for me is that if it moves to Schedule 3 right now, marijuana is a. It's illegal federally. Right. On a federal level, it's illegal. And so dispensaries, anybody in the cannabis industry cannot write off any business expenses because they are trafficking a, uh, federal, you know, a Schedule 1 substance that is federally illegal. When it moves to Schedule 3, they can write off all of their business expenses.
Speaker A: So we're going to see a boom in the number of businesses selling pocket. Right.
Speaker B: And, and the money increase. I mean, it's a hundred billion dollar industry pretty much both medically and. And, uh, recreationally. Wow.
Speaker A: M. So then what. Let's go back to Anders. He is hanging out with some friends. They're all experimenting with different drugs.
Speaker B: I'm, um.
Speaker A: Were any of them experiencing marijuana induced psychosis? Were any of them, you know, struggling with addiction? Did Anders know that he was addicted to cocaine and heroin?
Speaker B: He didn't know. He didn't know.
Speaker A: And by the way, let me just say a lot of people who are addicted are in denial about their own addiction.
Speaker B: Yes. And he was definitely in denial. And, and as many times, you know, his father and I, we, we had differences in opinion on how to deal with it. And I was very much, probably more to like, no, no, no, you know what I mean? I was that person that was like, don't do this, don't do this. And, um, wanted to do the intervention and all that. And none of it was getting through to him. None of it was. And he, uh. Yeah, it was on March. March 4th in 2019 that he, uh, he succumbed to his addiction and died from an accidental overdose. And so that, that day, though, you can think of it as. You can think of March 4th as a date or you can think of it. It was a command to me. A command to march forth in his honor and to, uh, to let other people know. And so then it was after that that his, his brother. It was about two years after that that his brother developed schizophrenia. So it's been. Yeah, this is my passion and my mission is really to educate kids and to educate par how beautiful and vulnerable the developing brain is.
Speaker A: Yeah. Oh, my gosh. Yeah. That I have two sons around your son's ages, and I can't even fathom.
Speaker B: Yeah, it is a, uh, something every single day. You know, I, I think there's not an hour that goes by that I don't think of both of them and, and, and you know, if I could go back, I just wish I could go back and do things actually now what I know I've learned so much with just researching about cannabis, researching about, you know, alcohol, nicotine, everything on the developing brain and just uh, the, the substances, stress and social media and, and, and screen time on the developing brain. It's. We really need to make a change and how our. What our children are given access to.
Speaker A: Mm. All right, so what would you have done differently if you could go back?
Speaker B: I would have, I would have tried to listen more. I would have tried to listen more and to understand his reasons. He, he honors had dealt with anxiety and some depression and I would have actually tried to really, instead of lecturing, to listen to tell him how much, you know, I loved him. And not as anybody who knows, who deals with someone who's in full blown addiction, how difficult that is. And uh, there's the tough love, there's all of that and it is so hard. It's so hard. So I would definitely have talked to him more and been open and just found any ways I could to teach him about his brain, to teach him about how he speaks to himself. Mhm. Yeah. Especially during those younger years and to teach him about how. What neuroplasticity is and how you have the ability to rewire the connections in your brain and change your neurocircuitry, all these things. I would have gone back and, and just telling him that this was this beautiful opportunity because the brain is incredibly plastic during adolescence and. But now this is what, you know, it's going to lecture to kids and telling them the, these are the things I would have told him if I had the chance. Now if I could go back, these are the five, you know, those kind of things I would tell him. So do you.
Speaker A: I saw an interview in which you said that you believed Anders would be alive today if he hadn't started smoking pot when he was 14, 15.
Speaker B: You know, I, I do believe that the psychosis that he had and whether it was a link between, you know, maybe there was a genetic predisposition, something I don't know, you know, down the line, and that he was using high potency cannabis and he was using when he was young, 13, the brain was much less developed and there could have been, um. Also there's epigenetics. Have you heard of that before? So just where. Which we found now with cannabis, it changes basically the decorations on your genes. So it doesn't actually change the DNA of the sequence on your genes, but it actually changes, um, how those genes turn on and off. So, uh, your genes are made to be turned on right at the right moment. Right. And turned off right at the right moment. Well, we found now with studies that actually THC changes that switch. So it changes the on and off switch of basically turning on and off those genes. And what we're seeing, that is those are resulting problems with learning and memory and emotion regulation and addiction, all of those things. And. And so I do believe that him using THC at that young age. I think epigenetics played a role in that as well.
Speaker A: Yeah, we know. I did. I remember doing an entire documentary on the female brain, and then in a whole another documentary on the male brain. And it was. I being fascinated by it because, uh, as the mother of two boys, the science around how the boy brain develops was it. It was so strikingly different from how a girl's brain develops. And one of the biggest things. And I think anybody who's done a teeny bit of reading on this knows you were talking a moment ago about that freak prefrontal cord. Yeah. The part of your brain, uh, where you understand consequences, the part of your brain where you understand danger properly does not develop even in a healthy boy, in a healthy young man, does not fully develop until, as you said, age 24 or 25. I mean, that's the thing that terrifies me the most, is that my sons, who are still both younger than that age, still might not recognize and understand the consequences, the. The very serious consequences of decisions and actions that they take and make.
Speaker B: Right.
Speaker A: When you layer in THC and then later on other drugs, what happens to that boy's brain?
Speaker B: Well, if I can get into what the endocannabinoid system does on a very. I'll do it on a very simple level.
Speaker A: Do it like cartoonishly kindergarten level. Okay, you got it.
Speaker B: Okay. So the endocannabinoid is basically a thermostat for the brain. What it does is, and particularly during adolescence, it actually serves as regulating all the communication in the brain. And so where the gas is needed and where brakes are needed, you know, in development, making sure that everything is communicating beautifully. All right, so it's a thermostat. If it gets too much gas, it says, oh, okay, we need to put a little, you know, take. Take the foot off the pedal. And. And same with the braking. When THC comes in, it takes over that communication. All right, so it takes over that communication. Now the important part about it is that the endocannabinoid system, so this beautiful system that works, and as your thermostat, it does it all on demand, only when it's needed. Okay? So if you're. If you have these neurons, those. Those. Those cells that are communicating with one another, right? If they are communicating too much, that system, the endocannabinoid system, will say, hey, we need to slow this down. And so then basically, that endocannabinoid system does its work and says, let's stop this communication right now. Let's decrease it. But now when THC comes into the brain, it takes over that communication. So it actually. That. Let's say that neuron's communicating, and it's not done. It needs to keep going for, we'll just say, another five minutes. What is going on? THC comes in, and it binds to the place where that endocannabinoid, that actual. That that molecule should bind to it to tell it to stop. It will bind to it before it is actually supposed to stop. So it goes in. As soon as they get high, it tells those neurons, uh, stop communicating with me. Even if it weren't supposed to stop, even we still needed gas, even if we still needed breaks. And so what happens is, is that there is, uh, a neuroplasticity in the brain. So basically just saying, neurons that fire together wire together. It's a simple way. When neurons communicate a lot, they basically wire together so that basically, you can strengthen that communication. The brain learns you. It learns you. It says, okay, what does my human do? A lot of whatever you do, a lot of the brain says, we want to keep this. And this is why we think about addiction in its own right. Right. I mean, my human is using this drug all the time, and they can reinforce that circuitry, and that's why it becomes so hard to stop. Right? So looking at it in reference to thc, when THC comes in, it's telling these neurons to stop communicating prematurely, whether or not it's needed. And what happens with the brain if those neurons are not communicating anymore, particularly during adolescence, those. Those commit. That communication area, uh, gets snipped. It's like, oh, this communication is not happening. The brain is trying to find the most beautiful way to develop and make it so the brain is efficient and quick. But if neurons are not communicating, it's like, well, we don't need this communication anymore. So what the brain.
Speaker A: What happens when the brain becomes inefficient like that? Like, so, like, they can't make decisions you can't recognize what is, like, anything
Speaker B: because you're looking at basically learning, memory processing, uh, reward, like, thinking of things like that. And. And what it does is because the whole purpose of that endocannabinoid system during adolescence is to basically bring that prefrontal cortex online and to fine tune it, make sure it's all communicating properly. THC is coming up and messing with the communication. It's hijacking the communication. And so, uh, the brain, you could think of it like, here's the endocannabinoid system working in the brain, the construction zone, and all these. All these, you know, machines are working and tractors, dump trucks. But then all of a sudden, THC comes in, like, in the form like Sam. They just dump it in m the middle of their construction zone. And the endocannabinoid system says, oh, my gosh, I gotta clean all this up. Like, I got to, like, try and clean all this up before I can keep developing the prefrontal cortex. And so what it's doing is it's delaying the development. So, yes, it is. It's affecting learning, it's affecting memory, it's affecting attention, it's affecting, you know, risk. It's affecting all of those things and judgment, everything. And what we've seen is, you know, I said that when neurons aren't communicating, they get snipped during adolescence.
Speaker A: I'm curious. We know that the. The brain and the body, the human body, at least parts of it, can show miraculous recovery from abuse of drugs or alcohol. Can the adolescent brain ever recover? If this teenager smoked a lot of pot between 14 and 19, like, in other words, if you can't, can it. Can it go back to normal?
Speaker B: What I'd say is that the brain is remarkable and that if paths have been, you know, cleared, your brain will rewire just like stroke. We look at recovery from things like that. And so the brain can find ways to. Can find ways to, uh, work around, you know, the damaged area. So I do think that that is possible fully. Uh, I can't comment on that because I don't know. You know, I don't know that actual answer. But I will say that when we look at adolescent use of cannabis, that we have seen an increase in anxiety, increase in depression, suicidal ideation, all of these. And, uh, so many kids that when I go and speak, most of them say, oh, I need to use. You know, I smoke weed because it helps me relax, it helps me be less anxious. But what we can think of is the fact that, yes, you're just you're covering up, right? You're, you're, um, you're masking your anxiety right now because I'll ask him, well, what happens after you've, after you're done, after, you know, m. After you're not high anymore? How do you feel? Well, anxious, I said, so you have to use again. And it's like, what about if we deal with, and this is all as society, if we could just learn that life is comfortable and uncomfortable and sometimes really boring, you know, and we need to learn as a society that this is okay. It's okay. And feeling uncomfortable, you know, you have to name it, to tame it. You got to figure out what that is. And you can't use substances or screens or whatever it might be to try and um, to get away from it because it's just going to keep chasing you down.
Speaker A: In today's age, and especially with our young people, it's not just alcohol or drugs. It's like you said, social media. You know, I want to lose myself in this world so I don't have to feel so uncomfortable in my own skin. And none of this stuff that we're escaping to or escaping with ultimately helps us. And in fact, in the case of Anders and so many other kids, it can hurt dramatically and drastically. And in Andrew's case, tragically.
Speaker B: Right. Well, and, and I do know that with, uh, my other son that he, you know, schizophrenia is a, it's a lifelong disorder and that's something that a lot of kids don't understand. You know, they, they think that, oh, well, you could have that psychosis and it's going to go away and then you'll be fine again. But, you know, and some kids are lucky. Sometimes it lasts for a couple months. And so that's where I say that, yeah, you can, you can see a change somewhere where kids will come back, you know, to reality. But, but like with, when you develop schizophrenia, it's, it's lifelong and you have that for forever.
Speaker A: So that never goes away.
Speaker B: Mhm. And so he's on medication for the rest of his life. And, and, and you believe he also
Speaker A: got this through using marijuana?
Speaker B: I believe that it was an association with it.
Speaker A: Association, yeah. Contribute.
Speaker B: Yeah, I think health contribute. And I think that' because we don't know. I mean, there's all this, there's this causal argument and you know, there's a lot of people on that side and there's a lot of people on. Well, we don't know yet. And I truly think we don't know yet. So I like to say that, yeah, it's, it definitely there's an association with it and whether or not you're just. It's almost the perfect storm of epigenetics and you know, maybe some genetic predisposition with using high potency, using younger, whatever it might be. But the psych, the psychosis, as I said, uh, it is more rare, but we're seeing more and more that is cannabis induced people coming into emergency departments that have psychosis and it is associated with them using, uh, marijuana.
Speaker A: I can only imagine how challenging it is for you to have another son who is struggling with a similar thing and who, you know, Anders, his life ended with this tragedy. I, I don't. I just have to ask. How do you, how do you live with not worrying incessantly and constantly about your surviving son?
Speaker B: Uh, I worry every moment. He's the, the, uh, in my prayers every single morning, every single night. Uh, when he doesn't call, you know, if I, if I text him or call him and I don't hear back, it's, uh, you know, mama bear kicks in. Like I've, I've got to know you're okay. And uh, it. But it's hard because when you have schizophrenia, it's, it's a very difficult, challenging disease. And he has been doing better though. He, it's been now almost two years since he's been hospitalized and he lives, he lives with me here in Nashville and I'm just, just so grateful to have him close. Uh, but he, he has difficulty just in daily functioning and, and all of that. But I will say I, I worry, I worry non stop and I just, I can't even, you know, I can't imagine. And he, he is very, I will say he's very proud about what I'm doing. He's very proud. You know, although he won't admit that he thinks it's. It's cannabis that caused, or I don't want to say caused. He. See, I caught myself that cannabis may have, you know, somehow triggered his psychosis and schizophrenia. He, he is, he's very proud about what I'm doing and that means the world to me.
Speaker A: The documentary is called Speaking Through Me. It's won several awards. How can people watch it?
Speaker B: If you Google Speaking Through Me documentary, it will take you to the, It'll pop up.
Speaker A: Yes, it's definitely worth a watch. You speak to a lot of, uh, young adults, teenagers, you know, young adults who, you know, struggled with anxiety, depression, who struggled with self medication and addiction and who came out the other side and have some really important and valuable advice on how to get there. Um, you've also started a nonprofit called 22 Forever in honor of Anders, who was 22 when he died. Tell me about the work of that organization.
Speaker B: So 22 forever will be a. Basically working on building a curriculum. So I'm trying to build a middle school brain health curriculum, and I have a great team, curriculum designers, all of that. And it, it is trying to teach kids about their. Their brain, their developing brain, what it means when people say your prefrontal cortex doesn't develop till you're 25. What is actually going on. To teach them about how, just like I said, the impact of screen, screen, uh, use, screen time, substance use, and also stress. You know, so, so few of us, even adults, understand that, you know, everything that we, uh, we say to ourselves or say to others, it's a choice. It's a choice that we make and, and how we look at ourselves and how we deal with stress. It's always a choice. I want to show them what neuroplasticity is and to show them that you can actually train your brain. Like you can actually train and grow parts of your brain, your hippocampus, which is your memory stores and learning. You can actually make that region grow. Do you know what I mean? Just based on. On like avoiding substances and things like that, but also just teaching them how, uh, we learn to take care of our bodies and our. In our heart and all of that, but to teach them how to. How to train your mind and what mindfulness is and importance of mindfulness, not in just saying, okay, you're going to breathe and it's going to make you feel better. But why teach them about the brain? How is this changing your brain? And really trying to put them in the driver's seat of being able to. To dictate who and how they want to be as an adult. So that's what I'm doing. And I, I'm just, you know, anything that I can. And honestly, that's what. If I just had to sit around, I would worry about Jonas all the time. And I do worry about him. But doing this gives me. It makes me feel closer to Anders, and it makes me feel closer to Jonas because, you know, I'm doing it for them. And then all the other kids, and there are so many who are suffering. And the latest CDC numbers showed 40% of high school students feel a sense of hopelessness and a sense of persistent sadness. 20% have seriously considered suicide, and 10% tried. That's. It's just not right. Something has to change. So I'm going to do whatever I can and I'm going to keep fighting as, as the mom that I am, because I don't want any other child or family to go through what I've been through.
Speaker A: Dr. Kristin Gilliland, thank you for joining us today, for sharing your story, and most importantly, for the work that you have done and continue to do to help kids and families everywhere who are dealing with this. Really appreciate it.
Speaker B: I'm so grateful to the partnership and to you and everything that you do and just, I, I, uh, am honored to be here and, and just thank you from the bottom of my heart.
Speaker A: Thank you. Thank you so much for listening to Heart of the Matter. If your child is struggling, our, uh, trained helpline specialists can help you navigate the challenges and find solutions. Visit our website@drugfree.org support for more info. As a reminder, you can find Heart of the Matter on Spotify, Apple Podcasts, and at, uh, drugfree. Org Podcast. And if you enjoy what you hear, please consider leaving us a rating on your favorite podcast platform. We'll talk to you soon.
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