The Best B2B Podcast Episodes

Tito Bohrt on building a world-class sales development org

Tito Bohrt, CEO of Alti Sales, discusses his framework for building and diagnosing sales development teams, focusing on behaviors, systems, messaging, and skills in that specific order. He shares data-driven strategies for improving cold calling pickup rates to 6%+ through caller ID optimization, power dialing, and call screener tactics, while emphasizing the importance of fixing foundational behaviors before training on skills.

How Kubernetes Custom Resource Definitions Cause Controller Memory Leaks

Lucas and Luna discuss how Kubernetes custom resource controllers commonly leak memory by storing pointers to objects from the shared informer cache, causing unbounded heap growth over days or weeks even when the controller logic itself appears clean.

AI Finds Vulns You Can't With Nicholas Carlini

Nicholas Carlini discusses how language models like Claude can now reliably find real vulnerabilities in code with minimal prompting, moving beyond the traditional fuzzing and manual analysis barrier-to-entry that once protected software from discovery.

Why Healthcare Prices Are Like Fight Club w/ Mark Cuban, Co-Founder, Cost Plus Drugs

Mark Cuban discusses how Cost Plus Drugs is disrupting pharmaceutical pricing by exposing the opaque markup system dominated by pharmacy benefit managers (PBMs), drug distributors, and brand manufacturers. He explains the mechanics of how list prices, rebates, and formulary control create artificially inflated prices for patients, and how his company's transparent cost-plus-15% model challenges this broken system.

How Kubernetes ResourceQuotas Cause Silent Pod Evictions

Kubernetes ResourceQuotas can silently evict running pods when namespace limits are exceeded, causing outages without obvious warning signs—a failure mode that an e-commerce team learned about the hard way during a flash sale that cost $200,000 in lost revenue.

Python Cryptography Breaks Up with OpenSSL with Paul Kehrer and Alex Gaynor

Paul Kehrer and Alex Gaynor, maintainers of the Python cryptography library, discuss their concerns with OpenSSL 3's design, focusing on complexity and performance regressions rather than security issues, and explain why they're implementing alternative solutions like HPKE support themselves.

226: Most Brands Are Chasing AI Visibility Backwards with Alisa Scharf, Chief AI Officer at Seer Interactive

Alisa Scharf, Chief AI Officer at Seer Interactive, argues that most brands are pursuing the wrong AI visibility strategy by chasing citations and rankings in LLM outputs rather than building accurate brand representation. Her research across 15,000+ prompts and 500,000+ pages reveals that lower domain authority sites often get more ChatGPT citations than established brands, and LLMs recommend brands only 2.3% of the time—a leading indicator metric that shouldn't drive strategy.

#19 - Brooklyn Zelenka: UCAN, Beehive, Beelay

Brooklyn Zelenka discusses UCAN (User Controlled Authorization Networks) and Beehive, two systems for enabling peer-to-peer authorization and access control in local-first, decentralized applications using cryptographic capabilities instead of centralized databases.

How B2B Brands Leak Revenue Through Missing Lead Scoring Signals

Most B2B marketing automation platforms only score about 12% of website visitors because they rely on form-submission signals, leaving 88% of site traffic completely invisible to lead scoring engines. By adding a parallel intent-based scoring model that tracks anonymous behavior signals like page visits, time on page, and return frequency, companies can recover significant hidden pipeline and improve conversion rates.

The Humanoids in Logistics Are Already Here

The episode explores real AI implementations in logistics through eight interviews, finding that the

Snorkelling for negative prices

Norwegian hydropower reservoirs in the south have fallen to decade-low levels after an exceptionally cold winter and minimal spring precipitation, flipping Norway from a net power exporter to importer for the first time in years. The episode examines whether this constitutes a genuine energy security crisis or if structural market dynamics—particularly the surge in continental solar and wind generation creating negative prices—will actually help conserve water and reduce the deficit.

The Silicon Ceiling: Why AI Stalls at the Frontline

The episode examines why AI adoption stalls between executives (75% weekly use) and frontline workers (51% weekly use), arguing the gap reflects a leadership and operational design failure rather than a technology problem. The hosts explore how sector-specific barriers—compliance in financial services, workflow trust in healthcare, hype theater in tech—require different governance approaches, and emphasize that adoption depends on permission, training, time, and redesigned workflows, not communication or enthusiasm.

Avik Roy on Healthcare, Debt, and the Math Washington Won’t Touch

Avik Roy, president of Freopp and healthcare policy expert, argues that the U.S. faces a fiscal debt crisis driven primarily by healthcare spending, with a maximum 20-year window before bond markets fail and the government can no longer borrow. He traces healthcare's cost inflation to post-WWII wage controls that incentivized employer-provided insurance, creating an unchecked "open bar" system that drove prices far beyond other developed nations despite greater per-capita subsidies.

Helsing with Jon Gjengset

Jon Gjengset, principal engineer at Helsing, discusses how the defense company uses Rust across its entire software stack for critical infrastructure including UAVs, fighter jet upgrades, and autonomous systems, contrasting greenfield Rust adoption at Helsing with the brownfield approach he experienced at AWS.

An Enlightened Approach to Hernia Surgery with Dr. Reinhorn and Dr. Fullington

Dr. Michael Reinhorn and Dr. Nora Fullington of Boston Hernia explain how their specialized practice has reimagined hernia care to solve cost, quality, and patient experience problems through expert diagnosis, tailored surgical approaches, and appropriate site-of-care decisions.

Ryan Lopopolo: OpenAI's Framework for Shipping Code at 70 PRs/Week

Ryan Lopopolo, a technical staff member at OpenAI, discusses harness engineering—the framework for deploying coding agents to produce high-quality, trustworthy code at scale. He shares how OpenAI ships 70+ PRs per week using agents with minimal human code review, relying instead on automated testing, linting, reviewer agents, and post-merge feedback loops to maintain quality.

S8E2 - When AI does the thinking, how do young people learn to be critical thinkers? The urgent warning for those under 25.

Elementary teacher Tim explores why young people are losing critical thinking skills as AI does their intellectual work for them. He distinguishes between cognitive atrophy (adults forgetting skills they've mastered) and cognitive foreclosure (children never developing skills in the first place), arguing the latter is permanent and should concern parents, educators, and organizations relying on human judgment.

AI Is Rewriting Addiction Treatment Marketing. Donald Prince Explains What’s Changing

Donald Prince, Chief Strategy Officer at Guardian Recovery, explains how AI and Google's AI Overviews have fundamentally changed addiction treatment marketing strategy, shifting focus from long-tail content pages to hyperlocal SEO and individual location domains while adapting to reduced organic traffic from featured snippets.

Are law firms ripe for Private Equity investment

Adil Taha, a PE operator in UK legal for nearly a decade, discusses why most PE law firm acquisitions have underperformed, arguing that while consumer-facing practices like family and personal injury law offer viable investment theses, the regional rollup strategy has failed due to overpayment, partner retention issues, and fundamental misunderstanding of law firm economics.

55X in 12 Months: The Clearing and Settlement Layer No One Is Rebuilding Till Now | George Davis, CEO and Co Foudner of Lorum

George Davis, CEO of Lorum, discusses how his company is rebuilding the clearing and settlement infrastructure that major banks have neglected—a layer that processes cross-border payments for fintech companies, remittance providers, and other financial institutions. Lorum operates as a 100% reserve-backed global custodian offering treasury services, FX execution, and account management at wholesale rates, having grown 55x in 12 months by making these services accessible to mid-market financial institutions previously shut out by the largest banks.

How API Webhook Delivery SLOs Create Hidden Reliability Risks

Webhook delivery SLOs based on percentiles like p99 can mask degradation affecting specific customers or endpoints, creating hidden reliability risks where tail latency creeps up without triggering alerts. The episode explores failure modes, real-world examples, and practical solutions including per-endpoint tracking, higher percentile thresholds, end-to-end tracing, and retry logic instrumentation.

#26 - Adam Fish: Ditto, Realm

Adam Fish, CEO of Ditto, discusses his 15-year journey building sync and data infrastructure, starting with a naive sync engine in a mobile CRM app, advancing through Realm's operational transformation approach, and now building Ditto as a CRDT-based edge sync platform designed for offline-first resilience and peer-to-peer connectivity.

Freemium at Scale: Why Life360 Protects its Free Users - Giordano Contestabile

Life360, a family safety app with 100 million MAU and $500M in annual revenue, prioritizes protecting its generous free tier while building growth as a company-wide system through experimentation and AI-driven personalization.

How Idempotency-Key Design Prevents Payment Disasters

A deep dive into idempotency-key design for payment processing, using a real case study where a SaaS company suffered double-charges despite using Stripe's idempotent API. The episode explores why naive key generation fails, how state machines complicate idempotency, and practical patterns for preventing payment disasters.

Threat Actors Leverage Behavioral Science; Security Teams Should, Too with Matt Wallaert

Matt Wallaert, founder of Besci.io and behavioral science expert, explains how security teams should apply behavioral science principles to reduce risk, specifically by identifying the actual behaviors that matter, understanding the promoting and inhibiting pressures that drive those behaviors, and avoiding biased assumptions about why people don't comply with security practices.