The Best B2B Podcast Episodes

Tito Bohrt on building a world-class sales development org

Tito Bohrt, CEO of Alti Sales, discusses his framework for building and diagnosing sales development teams, focusing on behaviors, systems, messaging, and skills in that specific order. He shares data-driven strategies for improving cold calling pickup rates to 6%+ through caller ID optimization, power dialing, and call screener tactics, while emphasizing the importance of fixing foundational behaviors before training on skills.

AI Finds Vulns You Can't With Nicholas Carlini

Nicholas Carlini discusses how language models like Claude can now reliably find real vulnerabilities in code with minimal prompting, moving beyond the traditional fuzzing and manual analysis barrier-to-entry that once protected software from discovery.

How Kubernetes Custom Resource Definitions Cause Controller Memory Leaks

Lucas and Luna discuss how Kubernetes custom resource controllers commonly leak memory by storing pointers to objects from the shared informer cache, causing unbounded heap growth over days or weeks even when the controller logic itself appears clean.

Interview: Brooking’s Aaron Klein on Faster Payments, Consumer Credit & the Fed

Aaron Klein, a senior fellow at Brookings Institution with deep experience in financial regulation, argues that the Federal Reserve has deliberately prevented real-time payments in the US in violation of law, because slower payments drive overdraft fees that generate over $100 billion in wealth extraction from low-income Americans. He traces how overdraft transformed from a courtesy to a profit center, and connects slow payment systems to the explosion of alternative credit products like payday lending and fintech apps.

This CPO regrets that product management exists | Tom Verrilli (CPO of Whatnot)

Tom Verrilli, CPO of Whatnot, argues that product management as a widespread specialist function is fundamentally flawed—most teams shouldn't have dedicated PMs, and the role should only exist where there's a specific need. He instead advocates for empowering engineers and designers to make product decisions themselves, building this philosophy directly into Whatnot's org structure where PMs are allocated to problems, not teams, and reassigned every six months.

Why Healthcare Prices Are Like Fight Club w/ Mark Cuban, Co-Founder, Cost Plus Drugs

Mark Cuban discusses how Cost Plus Drugs is disrupting pharmaceutical pricing by exposing the opaque markup system dominated by pharmacy benefit managers (PBMs), drug distributors, and brand manufacturers. He explains the mechanics of how list prices, rebates, and formulary control create artificially inflated prices for patients, and how his company's transparent cost-plus-15% model challenges this broken system.

The Ghost Network Behind Pediatric Home Nursing: When Authorized Hours Go Unfilled

This episode examines the gap between authorized and actually delivered pediatric home nursing hours in Medicaid managed care, revealing that health plan directories list hundreds of agencies but only a fraction can actually staff medically complex pediatric cases, leaving children stranded in hospitals despite discharge readiness.

226: Most Brands Are Chasing AI Visibility Backwards with Alisa Scharf, Chief AI Officer at Seer Interactive

Alisa Scharf, Chief AI Officer at Seer Interactive, argues that most brands are pursuing the wrong AI visibility strategy by chasing citations and rankings in LLM outputs rather than building accurate brand representation. Her research across 15,000+ prompts and 500,000+ pages reveals that lower domain authority sites often get more ChatGPT citations than established brands, and LLMs recommend brands only 2.3% of the time—a leading indicator metric that shouldn't drive strategy.

How Kubernetes ResourceQuotas Cause Silent Pod Evictions

Kubernetes ResourceQuotas can silently evict running pods when namespace limits are exceeded, causing outages without obvious warning signs—a failure mode that an e-commerce team learned about the hard way during a flash sale that cost $200,000 in lost revenue.

Python Cryptography Breaks Up with OpenSSL with Paul Kehrer and Alex Gaynor

Paul Kehrer and Alex Gaynor, maintainers of the Python cryptography library, discuss their concerns with OpenSSL 3's design, focusing on complexity and performance regressions rather than security issues, and explain why they're implementing alternative solutions like HPKE support themselves.

Win the AI Answer, Not Just the Citations with Tim Sanders, Chief Innovation Officer at G2 - Ep 85

Tim Sanders, Chief Innovation Officer at G2, discusses answer engine optimization (AEO) and how companies should adapt their go-to-market strategies for AI-driven search. He emphasizes that blocking AI crawlers is strategically shortsighted—G2 unblocked their content for ChatGPT and Gemini, becoming a top citation source for software recommendations and demonstrating that expected value analysis should drive accessibility decisions.

The Silicon Ceiling: Why AI Stalls at the Frontline

The episode examines why AI adoption stalls between executives (75% weekly use) and frontline workers (51% weekly use), arguing the gap reflects a leadership and operational design failure rather than a technology problem. The hosts explore how sector-specific barriers—compliance in financial services, workflow trust in healthcare, hype theater in tech—require different governance approaches, and emphasize that adoption depends on permission, training, time, and redesigned workflows, not communication or enthusiasm.

$340k to $1.3m of Earnings in 14 Months

Rob Brooks, a former Fortune 500 operations executive, acquired a 31-year-old HVAC service business in Sarasota, Florida with $340k EBITDA and grew it to $1.3m in 14 months by getting deeply operational—learning the trade in person, working midnight service calls with technicians, and ruthlessly eliminating inefficiency starting week one.

The Humanoids in Logistics Are Already Here

The episode explores real AI implementations in logistics through eight interviews, finding that the

Snorkelling for negative prices

Norwegian hydropower reservoirs in the south have fallen to decade-low levels after an exceptionally cold winter and minimal spring precipitation, flipping Norway from a net power exporter to importer for the first time in years. The episode examines whether this constitutes a genuine energy security crisis or if structural market dynamics—particularly the surge in continental solar and wind generation creating negative prices—will actually help conserve water and reduce the deficit.

#19 - Brooklyn Zelenka: UCAN, Beehive, Beelay

Brooklyn Zelenka discusses UCAN (User Controlled Authorization Networks) and Beehive, two systems for enabling peer-to-peer authorization and access control in local-first, decentralized applications using cryptographic capabilities instead of centralized databases.

Episode 125: Avik Roy on Healthcare, Debt, and the Math Washington Won’t Touch

Avik Roy, president of Freopp and healthcare policy expert, argues that the U.S. faces a fiscal debt crisis driven primarily by healthcare spending, with a maximum 20-year window before bond markets fail and the government can no longer borrow. He traces healthcare's cost inflation to post-WWII wage controls that incentivized employer-provided insurance, creating an unchecked "open bar" system that drove prices far beyond other developed nations despite greater per-capita subsidies.

How B2B Brands Leak Revenue Through Missing Lead Scoring Signals

Most B2B marketing automation platforms only score about 12% of website visitors because they rely on form-submission signals, leaving 88% of site traffic completely invisible to lead scoring engines. By adding a parallel intent-based scoring model that tracks anonymous behavior signals like page visits, time on page, and return frequency, companies can recover significant hidden pipeline and improve conversion rates.

EP 251: Cracking the delivery barrier in genetic medicine with Jagesh Shah of Mirai Bio

Jagesh Shah, Chief Scientific Officer at Mirai Bio, discusses how his company is tackling delivery as the central bottleneck in gene therapy by engineering lipid nanoparticles with modular designs, machine learning optimization, and programmable tropism to reach difficult tissues like muscle, brain, and immune cells.

104: From Particle Physics to AI: Rewiring How Organisations Work with Markus Bernhardt (Endeavour Intelligence)

Markus Bernhardt, founder of Endeavour Intelligence, argues that AI adoption fails when organizations swap tools without redesigning their operating models—governance, decision rights, and workflows. Unlike previous technology waves that required tool adoption, AI rewires how work actually happens, often invisibly, shifting tasks long before it changes org charts or job titles.

S8E2 - When AI does the thinking, how do young people learn to be critical thinkers? The urgent warning for those under 25.

Elementary teacher Tim explores why young people are losing critical thinking skills as AI does their intellectual work for them. He distinguishes between cognitive atrophy (adults forgetting skills they've mastered) and cognitive foreclosure (children never developing skills in the first place), arguing the latter is permanent and should concern parents, educators, and organizations relying on human judgment.

Are law firms ripe for Private Equity investment

Adil Taha, a PE operator in UK legal for nearly a decade, discusses why most PE law firm acquisitions have underperformed, arguing that while consumer-facing practices like family and personal injury law offer viable investment theses, the regional rollup strategy has failed due to overpayment, partner retention issues, and fundamental misunderstanding of law firm economics.

Helsing with Jon Gjengset

Jon Gjengset, principal engineer at Helsing, discusses how the defense company uses Rust across its entire software stack for critical infrastructure including UAVs, fighter jet upgrades, and autonomous systems, contrasting greenfield Rust adoption at Helsing with the brownfield approach he experienced at AWS.

Theodore Christakis: chatbot privacy dreams and the health AI agent rush

Theodore Christakis discusses his comprehensive research on privacy risks in chatbot conversations, examining both how AI providers handle user data internally and the external threats from law enforcement, data breaches, and litigation, while also addressing the emerging health AI agent market.

55X in 12 Months: The Clearing and Settlement Layer No One Is Rebuilding Till Now | George Davis, CEO and Co Foudner of Lorum

George Davis, CEO of Lorum, discusses how his company is rebuilding the clearing and settlement infrastructure that major banks have neglected—a layer that processes cross-border payments for fintech companies, remittance providers, and other financial institutions. Lorum operates as a 100% reserve-backed global custodian offering treasury services, FX execution, and account management at wholesale rates, having grown 55x in 12 months by making these services accessible to mid-market financial institutions previously shut out by the largest banks.