Why VCs Are Betting on De-Extinction Startups in 2026

Episode notes

Colossal Biosciences is reportedly raising at a $20B to $30B valuation. Lucas and Luna break down the venture logic behind de-extinction: the science, the spinouts in gene editing and synthetic biology, and the parallels to longevity biotech. They examine whether Colossal's valuation is backed by real platform potential or hype, referencing the latest headlines and the broader VC appetite for frontier tech. The episode also touches on how VCs underwrite risk when the product is resurrecting the woolly mammoth. #DeExtinction #ColossalBiosciences #VentureCapital #StartupInvesting #GeneEditing #SyntheticBiology #LongevityBiotech #Biotech #Valuation #FrontierTech #Science #Business #Technology #FexingoBusiness #BusinessPodcast #VCPodcast #TermSheets #Startup Keep every episode free: buymeacoffee.com/fexingo

Related episodes across the Index

Other episodes covering the same guests and topics, from across The B2B Podcast Index.

• Pat McGovern - Bowery Capital - Where Vertical AI WinsCloud Returns · on Venture capital87 / 100
• EP 244: Building the first n-of-1 ASO: The new frontier of rare disease with Timothy Yu of Boston Children’s HospitalThe Genetics Podcast · on Gene editing84 / 100
• The Autonomous Digital Economy Is HereFinding Peak w/ Ryan Hanley · on Venture capital82 / 100
• Quitting vs. Giving Up with Mike Evans, the Founder of GrubHubFounders Forward Podcast · on Venture capital82 / 100
• The Truth About Bootstrapping an AI Startup with David Pourquery (#80)Exit Algorithms · on Venture capital81 / 100
• The Mission Generation Wants Impact. Must They Choose Between Tech and Public Service? - Arun Gupta, CEO of NobleReach FoundationThe TechEd Podcast · on Venture capital81 / 100

• Synthetic User Startups Are Venture Capital's New Frontier44 / 100
• Why VCs Are Betting on Private Space Pilots for the US Space Force76 / 100
• Why VCs Are Backing Niche AI Copilots for Every Industry72 / 100
• The Bending Spoons IPO and Why VCs Love Bootstrapped Startups60 / 100
• Why VCs Are Betting on Together AI's 800 Million Round74 / 100