Is the ChatGPT Era Over? Opus 4.6 & The Shift from Chat to Delegation - EP99.33

Episode notes

Join Simtheory: Register for the STILL RELEVANT tour: It's the model same-day showdown of 2026. Opus 4.6 and Codex 5.3 dropped within minutes of each other, and we're breaking down what this means for the future of AI work. In this episode, we unpack Opus 4.6's million-token context window (if you've got billies in the bank), why Codex's pricing makes it nearly impossible to ignore for agentic loops, and the real cost of running agents for 24 hours ($10K, apparently). We dive deep into why coding-optimized models are secretly crushing it at non-coding tasks, the mental fatigue of managing AI workers, and whether the chatbot era is actually fading or just evolving. Plus: Chris accidentally books three real pig grooming appointments, we debate whether you need a "life coach agent" to manage your agent swarm, and yes - there's an Opus 4.6 diss track that goes unreasonably hard.

Related episodes across the Index

Other episodes covering the same guests and topics, from across The B2B Podcast Index.

• Ep 93: CEO of Redwood Research Buck Shlegeris on OpenAI/HuggingFace Revelations, Fixing AI Safety & Takeover OddsUnsupervised Learning with Jacob Effron · on OpenAI98 / 100
• The 18x Midas Lister Betting $3B on AI (and calling most of it fake) | Navin Chaddha, MayfieldThe Peel with Turner Novak · on OpenAI91 / 100
• Paul Graham On Startups, Ambition, and Great FoundersY Combinator Startup Podcast · on OpenAI88 / 100
• How SSW turned AI into ½ their pipeline - Ulysses Maclaren, COO of SSWSaaS Stories · on OpenAI86 / 100
• EP 148: Is the AI boom cracking? Inside July’s sell-off and beyondBeyond the Benchmark by EFG · on OpenAI85 / 100
• Unscripted with Victor: Agentic AI, Fintech's Future, and the Death of the App EconomyVentures from The Valley · on OpenAI83 / 100

• Is GPT-5.5 Better Than Opus Now? (ft. Our New AI Co-Host) - EP99.3852 / 100
• We Committed Fraud with OpenAI's New Image Model (and Called Mum) - EP99.3848 / 100
• We Built Microsoft Teams in 23 Minutes (And You Can Use It) & GPT 5.4 Impressions - EP99.37
• Nano Banana 2 is Here! Gemini-3 Shutdown & The AI Layoff Myth | EP99.36
• Gemini 3.1 Pro, Claude Sonnet 4.6 & The OpenClaw Hire That Killed the Chatbot Era - EP99.35