Reversing Humanity’s #1 Killer - Arterial Plaque | Dr. Matthew O’Connor, Ph.D. - CEO and Co-Founder - Cyclarity Therapeutics

Episode notes

Send us Fan Mail In the time it will take you watch this episode, over 2,000 people around the world will die from diseases driven by arterial plaque. But what if we could actually remove the toxic cholesterol already trapped inside arteries? Today we’re diving into one of the biggest unsolved problems in medicine and aging: how do you actually remove arterial plaque instead of merely slowing its progression? Cardiovascular disease remains the world’s leading killer, despite decades of statins, anti-inflammatory drugs, and newer RNA-based therapies. Most existing treatments help manage cholesterol and reduce risk, but very few directly target the toxic debris already embedded inside plaques. But what if we could literally extract some of the most dangerous oxidized cholesterol molecules from the body? My guest today is Dr. Matthew ‘Oki’ O’Connor, Ph.D. - CEO and Co-Founder of Cyclarity Therapeutics ( ), a biotech company developing engineered cyclodextrin molecules designed to bind and remove 7-ketocholesterol, or 7KC - a toxic oxidized cholesterol strongly implicated in atherosclerosis, inflammation, plaque instability, and even broader age-related diseases.

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