Progress, Potential, and Possibilities Podcast / Show · 2026-05-29 · 50 min
Send us Fan Mail What if medicines could actually “decide” when and where to activate inside the body? MIT-trained synthetic biologist Dr. Jacob Becraft, Ph.D. is building programmable therapies that behave less like traditional drugs…and more like biological software. Dr. Becraft is Co-Founder and CEO of Strand Therapeutics ( ), a company pioneering what may become one of the next great frontiers in medicine: programmable mRNA therapeutics. Long before mRNA became a household term through COVID vaccines, Dr. Becraft and his colleagues at MIT were developing what has been described as the world’s first synthetic biology programming language for mRNA - technology designed not simply to deliver genetic instructions, but to create logic-driven therapies capable of making decisions inside living cells. Now Strand is translating that vision into cancer therapeutics, with early clinical data from its lead candidate STX-001 showing responses in patients with advanced solid tumors who had exhausted conventional options - including evidence of systemic immune activity and even complete responses.
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