Positive Leadership · 2026-06-10 · 1h 27m
In 2011, Stéphane Bancel walked away from the security of leading a 6,000-person diagnostics company to join a startup of about 50 people, built on an idea most scientists had dismissed: that messenger RNA could become medicine. Almost everyone told him not to do it. He gave the bet roughly a five percent chance. Nine years later, that same bet helped the world face a pandemic in 63 days. Stéphane Bancel is the Chief Executive Officer of Moderna. Under his leadership the company designed a COVID-19 vaccine on a computer within days of the genetic sequence being posted, delivered the first dose to a human just 63 days later, and scaled from zero manufacturing to a billion doses in twelve months. Today Moderna is building personalized cancer vaccines and using AI to reinvent how medicines are discovered and made. This conversation sits right at the heart of what I believe about leadership. That the chief executive is really the chief energy officer. That the boldest decisions are rarely about appetite for risk, they are about the asymmetry between what you could give the world and what you could actually lose.
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