658. Preventing Alzheimer's: Bridging Research and Practice with Dr. Dale Bredesen

Episode notes

Dale Bredesen is the senior director of the Precision Brain Health Program at Pacific Neuroscience Institute and also the founding CEO of the Buck Institute. He also has authored a number of books, including, most recently, The Ageless Brain: How to Sharpen and Protect Your Mind for a Lifetime and The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline . Greg and Dale discuss Dale’s “network insufficiency” view of Alzheimer’s that shifts focus from plaques alone to a balance of synaptic “supply and demand.” He argues the brain switches from connection to protection under chronic insults, which are microbes, inflammation, toxins, metabolic syndrome, sleep apnea, and poor energetics. Dale highlights tau phosphorylation as part of an antimicrobial response and APOE4 as a pro-inflammatory risk gene with evolutionary benefits. They also discuss diet, insulin resistance, exercise, sleep metrics, stress, and the case for prevention and combined approaches. *unSILOed Podcast is