🧬 From VC to Operator: The Career Move Nobody Recommended | Caleb Appleton (Part 3/4)

Episode notes

The Biotech Startups Podcast is powered by Excedr —helping life science startups accelerate R&D and commercialization with founder-friendly equipment leasing. Skip the upfront costs, stay lean, and focus on breakthrough science. As a TBSP listener, you can get exclusive perks through Excedr’s partner network—special savings, promotions, and more. Explore these offers today: . "If you're making a good decision, it will usually feel liberating; if you're making a bad decision, it will usually feel constraining." In this episode of The Biotech Startups Podcast, we explore Partner at Bison Ventures, Caleb Appleton 's journey from venture capital to operations and back again. Caleb shares his experience joining Innovation Endeavors during its spinout from Eric Schmidt's family office, where minimal structure forced him to rapidly master sourcing, diligence, and thesis-building—including a cold email that landed a multibillion-dollar investment in Eikon Therapeutics.